[The effect of temazepam on the functional capacity and metabolic and cardiocirculatory parameters in consideration of the "jet lag" syndrome].

In a double-blind placebo controlled study, 14 male healthy volunteers were examined the morning after they had received an evening dose of 20 mg temazepam (Planum) with regard to functional capacity, cardial, cardiovascular and respiratory regulation as well as neuromuscular excitability and metabolic changes. After being exposed to the bicycle ergometer load, oxygen uptake, carbon dioxide output, glucose and lactate concentration were determined; furthermore the neuromuscular excitability of the musculus vastus medialis, musculus rectus femoris and musculus quadrizeps femoris was estimated. Despite unimportant capacity reductions (p greater than 0.05) concerning the maximum capacity (2.2%) as well as the maximum oxygen uptake (4.3%) under treatment with temazepam, there could not be proved any significant changes regarding cardiopulmonary and metabolic functions. On eastern and western flights, top athletes showed a very fast adaptation to the day-night rhythm without hang-over.
AuthorsJ Keul, L Rokitzki, E Jakob, W Stockhausen
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 38 Issue 7 Pg. 919-22 (Jul 1988) ISSN: 0004-4172 [Print] GERMANY, WEST
Vernacular TitleWirkung von Temazepam auf das Leistungsverhalten sowie metabolische und kardiozirkulatorische Grössen unter Berücksichtigung des "Jet lag"-Syndroms.
PMID2905133 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Anti-Anxiety Agents
  • Temazepam
  • Adult
  • Anti-Anxiety Agents (pharmacology)
  • Blood Gas Analysis
  • Circadian Rhythm
  • Clinical Trials as Topic
  • Coronary Circulation (drug effects)
  • Double-Blind Method
  • Exercise Test
  • Hemodynamics (drug effects)
  • Humans
  • Male
  • Muscles (drug effects)
  • Oxygen Consumption (drug effects)
  • Random Allocation
  • Respiratory Function Tests
  • Temazepam (pharmacology)
  • Travel
  • Water-Electrolyte Balance (drug effects)

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