Berenil (diminazene aceturate)-resistant Trypanosoma congolense in cattle under natural tsetse challenge at Kibaha, Tanzania.

Abstract

Twenty-nine cattle, naturally infected with Trypanosoma congolense Kibaha, were subjected to chemotherapy with diminazene aceturate (Berenil, Hoechst) at 3.5 to 14.0 mg/kg. Fourteen animals recovered while six were refractory to treatment at 7.0 to 14.0 mg/kg. Further treatment of the Berenil-resistant isolates with isometamidium chloride (Samorin, May and Baker) at 1.0 mg/kg, effected cure. Corresponding chemotherapeutic trials in mice showed that the isolates were resistant to diminazene aceturate at 56.0 mg/kg and sensitive to Samorin at 20.0 mg/kg. It is noted, that T. congolense infections that do not respond to treatment with Berenil at 7.0 mg/kg may indicate development of resistance; the use of Samorin at 1.0 mg/kg or Homidium may be the alternative. The paper calls for judicious use of Berenil and Samorin, as they are the only sanative pairs available for the chemotherapy of bovine trypanosomiasis.

• Authors: H A Mbwambo, P N Mella, K A Lekaki
• Journal: Acta tropica (Acta Trop) Vol. 45 Issue 3 Pg. 239-44 (Sep 1988) ISSN: 0001-706X [Print] Netherlands
• PMID: 2903625 (Publication Type: Journal Article)

Chemical References

• Amidines
• Phenanthridines
• Trypanocidal Agents
• isometamidium chloride
• diminazene aceturate
• Diminazene

Topics

• Amidines (therapeutic use)
• Animals
• Cattle
• Diminazene (analogs & derivatives, pharmacology, therapeutic use)
• Drug Resistance
• Mice
• Phenanthridines (therapeutic use)
• Tanzania
• Trypanocidal Agents (pharmacology, therapeutic use)
• Trypanosoma congolense (drug effects)
• Trypanosomiasis, African (drug therapy, veterinary)
• Trypanosomiasis, Bovine (drug therapy)