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Malignant pancreatic somatostatinoma in a patient with dermatitis herpetiformis and coeliac disease.

Abstract
A case of malignant somatostatinoma is reported in a patient with long-standing dermatitis herpetiformis and coeliac disease. The patient had non-specific abdominal pain of several years duration and came to attention because of weight loss despite strict adherence to a gluten-free diet. Plasma somatostatin levels were raised, and laparotomy showed a pancreatic tumour with metastases, which on histology, electron microscopy and immunohistochemistry proved to be a somatostatinoma. After a promising initial response to streptozotocin, she died 30 months later. This is the first reported occurrence of a somatostatinoma in a patient with coeliac disease, adding to the growing list of neoplastic complications in this condition.
AuthorsS Levi, I Bjarnason, C M Swinson, J M Polak, W Murray, A J Levi
JournalDigestion (Digestion) Vol. 39 Issue 1 Pg. 1-6 ( 1988) ISSN: 0012-2823 [Print] Switzerland
PMID2899527 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Somatostatin
  • Streptozocin
Topics
  • Adenoma, Islet Cell (complications)
  • Celiac Disease (complications)
  • Dermatitis Herpetiformis (complications)
  • Female
  • Humans
  • Middle Aged
  • Pancreatic Neoplasms (complications, metabolism, pathology)
  • Somatostatin (metabolism)
  • Somatostatinoma (complications, metabolism, pathology)
  • Streptozocin (therapeutic use)

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