DNA polymorphism and the study of disease associations.

Abstract	Recombinant DNA approaches to disease analysis may be as applicable to studies of disease association as they are to the analysis and diagnosis of single-gene defects. Population and/or family association analyses, using restriction fragment length polymorphisms around candidate genes as markers, have been employed to study conditions such as atherosclerosis and disease with an HLA-association. Progress made to date in disease-association studies using recombinant DNA methodology is reviewed, the rationale behind such studies is examined and associated problems and pitfalls discussed.
Authors	D N Cooper, J F Clayton
Journal	Human genetics (Hum Genet) Vol. 78 Issue 4 Pg. 299-312 (Apr 1988) ISSN: 0340-6717 [Print] Germany
PMID	2896152 (Publication Type: Journal Article, Review)
Chemical References	DNA, Recombinant Genetic Markers HLA Antigens DNA
Topics	Alleles Arteriosclerosis (genetics) DNA (analysis) DNA, Recombinant Disease Susceptibility (diagnosis) Ethics, Medical Gene Frequency Genetic Diseases, Inborn (genetics) Genetic Linkage Genetic Markers Genetic Predisposition to Disease HLA Antigens (genetics) Humans Models, Genetic Polymorphism, Genetic Polymorphism, Restriction Fragment Length

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