Somatostatin secretion in cultured human islet cells from patients with nesidioblastosis: a compensatory mechanism?

Abstract

Two patients with nesidioblastosis, one with persistent hypoglycemia and another who was asymptomatic, underwent pancreatic resection. Dispersed pancreatic islets were prepared from each patient. Insulin secretion from cultured islet cells was increased and somatostatin decreased in the symptomatic patient compared with the asymptomatic patient. Immunocytochemistry showed increased somatostatin-containing cells in the asymptomatic patient. We hypothesize that this may be the mechanism by which some patients with nesidioblastosis maintain normal serum glucose levels.

• Authors: J R Upp Jr, J Ishizuka, T E Lobe, S Rajaraman, C M Townsend Jr, J C Thompson
• Journal: Journal of pediatric surgery (J Pediatr Surg) Vol. 22 Issue 12 Pg. 1185-6 (Dec 1987) ISSN: 0022-3468 [Print] United States
• PMID: 2894424 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Insulin
• Somatostatin

Topics

• Cell Separation
• Cells, Cultured
• Child
• Child, Preschool
• Female
• Humans
• Insulin (metabolism)
• Insulin Secretion
• Islets of Langerhans (metabolism, pathology)
• Pancreas (cytology, metabolism, surgery)
• Pancreatic Diseases (metabolism, pathology)
• Somatostatin (metabolism)