Bidirectional transfer between kindling induced by excitatory amino acids and electrical stimulation.

Abstract

Chemical (C) kindling by means of repeated spaced injections into the amygdala (AM) of a subconvulsive dose of L-glutamate and L-aspartate combined in a molar ratio of 1:3. (Glu/Asp) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled Stage 5 seizure in rats. These C-kindled AM sites responded readily to electrical stimulation with very rapid development of kindled seizure. When a separate group of rats electrically kindled at the AM were subjected to identical C-kindling at the kindled AM site, a similar positive transfer effect was observed. In addition, 30 days following the last injection, kindled Stage 5 seizure was triggered with a single injection of Glu/Asp, one-half of the dose used for C-kindling. These results suggest that the glutamate and/or aspartate systems participate in the development and persistence of increased seizure susceptibility induced by AM kindling.

• Authors: N Mori, J A Wada
• Journal: Brain research (Brain Res) Vol. 425 Issue 1 Pg. 45-8 (Nov 03 1987) ISSN: 0006-8993 [Print] Netherlands
• PMID: 2892570 (Publication Type: Journal Article)

Chemical References

• Glutamates
• Aspartic Acid
• Glutamic Acid

Topics

• Amygdala (physiology)
• Animals
• Aspartic Acid (pharmacology)
• Electric Stimulation
• Glutamates (pharmacology)
• Glutamic Acid
• Injections
• Kindling, Neurologic
• Male
• Rats
• Rats, Inbred Strains