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Efficacy and safety of 153Sm-EDTMP as treatment of painful bone metastasis: a large single-center study.

AbstractPURPOSE:
The purpose of this study is to assess the efficacy of 153Sm-EDTMP (Quadramet®) in a clinical setting.
METHODS:
We have conducted a retrospective study of all consecutive patients (pts) treated with 153Sm-EDTMP for painful bone metastases. At each visit (before and after treatment), four parameters were collected: (i) pain assessment according to the 10-step visual analogue scale (VAS), (ii) sleep disturbance related to pain, (iii) dose of analgesic medication, and (iv) answer to the following closed question "Do you think you obtained a benefit from treatment?" Success of treatment was defined by the combination of these four parameters.
RESULTS:
Three hundred seventy consecutive 153Sm-EDTMP treatments for painful bone metastases were given. Patients had the following primary tumors: breast carcinoma (153), prostate carcinoma (155), lung carcinoma (27), or other cancers (35). Fifty-eight percent of the patients had received previous external osseous radiotherapy. Ninety-seven percent of the patients were treated with concomitant analgesics and 61% were treated with diphosphonates. A clinical benefit was described in 55.0% of cases at D30. Treatment was more effective in cases of breast and prostate cancers compared with other types of primary cancers. Patients described a benefit at D30 in 62, 58, 6, and 38% of cases of breast, prostate, lung, and other cancers. The subjective efficacy was accompanied by a decrease in analgesic intake in 35.0% of cases.
CONCLUSION:
153Sm-EDTMP therapy is an effective supportive treatment in patients who suffer from bone metastases, especially in patients with breast or prostate cancer.
AuthorsHélène Kolesnikov-Gauthier, Nathalie Lemoine, Emmanuelle Tresch-Bruneel, Anaïs Olivier, Aurore Oudoux, Nicolas Penel
JournalSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (Support Care Cancer) Vol. 26 Issue 3 Pg. 751-758 (Mar 2018) ISSN: 1433-7339 [Electronic] Germany
PMID28920149 (Publication Type: Journal Article)
Chemical References
  • Radioisotopes
  • Samarium
  • Samarium-153
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Bone Neoplasms (drug therapy, secondary)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain (drug therapy)
  • Radioisotopes (pharmacology, therapeutic use)
  • Retrospective Studies
  • Samarium (pharmacology, therapeutic use)
  • Treatment Outcome

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