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[A case of adult T-cell leukemia achieving complete remission with epirubicin, vincristine and prednisolone chemotherapy].

Abstract
A 68-year-old man was referred to our hospital because of generalized lymphadenopathy. His abnormal findings were hepatomegaly, leukocytosis and elevated serum LDH. Anti-ATLA antibody was positive. As about half of the peripheral lymphocytes reacted to the monoclonal antibody CD25, these cells were considered to be compatible with ATL cells having an interleukin-2 receptor. Initially, recombinant beta-interferon was administered, but it was not effective. A combination of vincristine (VCR) and prednisolone (PDN) was partially effective against the lymphadenopathy, but the hepatomegaly and leukocytosis did not improve. 4'-epi-Adriamycin (Epirubicin), at a doses of 20 mg/body, weekly, was subsequently added to VCR + PDN therapy. The patient achieved complete regression 2 months later, and has been in continuous complete remission for more than 3 months.
AuthorsK Okabe, H Toki, M Fujii, K Kiura, H Kamei
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 14 Issue 9 Pg. 2792-5 (Sep 1987) ISSN: 0385-0684 [Print] Japan
PMID2888435 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Epirubicin
  • Vincristine
  • Doxorubicin
  • Prednisolone
Topics
  • Aged
  • Deltaretrovirus Infections (drug therapy)
  • Doxorubicin (administration & dosage)
  • Drug Therapy, Combination
  • Epirubicin
  • Humans
  • Male
  • Prednisolone (administration & dosage)
  • Remission Induction
  • Vincristine (administration & dosage)

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