Comparison of preventive use of metronidazole and ampicillin in women with a history of pelvic inflammatory disease undergoing first-trimester abortion.

Abstract

In a double-blind controlled trial the efficacy of prophylactic metronidazole and pivampicillin to women with a history of pelvic inflammatory disease (PID) undergoing first-trimester abortion was assessed. Thirty-eight women received pivampicillin tablets 350 mg and 43 women metronidazole tablets 400 mg, given 1 h before and 4 and 8 h after the abortion. In the pivampicillin group 5 women (13.1%) and in the metronidazole group 8 women (18.6%) developed post-abortal PID, a non-significant difference (P greater than 0.05). The number of hospital days and amounts of antibiotics were not significantly different in the two treatment groups (all P-values greater than 0.05). Women with a history of PID were found to be at risk of contracting postabortal PID.

• Authors: L Heisterberg, K Petersen, S S Sørensen, D Nielsen
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 24 Issue 5 Pg. 343-6 (Oct 1986) ISSN: 0020-7292 [Print] United States
• PMID: 2880767 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Pivampicillin
• Metronidazole
• Ampicillin

Topics

• Abortion, Induced (adverse effects)
• Adult
• Ampicillin (analogs & derivatives)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Metronidazole (therapeutic use)
• Pelvic Inflammatory Disease (prevention & control)
• Pivampicillin (therapeutic use)
• Pregnancy
• Pregnancy Trimester, First
• Premedication