HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia.

Abstract
Excitatory amino acid neurotransmitters have been implicated in fostering brain edema and neuronal death in ischemia. As both of these processes are involved in nervous system damage during neonatal anoxia, the effect of blockade of cell excitation with kynurenate upon brain water was studied following anoxic-ischemic brain injury in neonatal rats. Such treatment attenuated brain edema immediately after, and 24 h following anoxia-ischemia.
AuthorsR P Simon, R S Young, S Stout, J Cheng
JournalNeuroscience letters (Neurosci Lett) Vol. 71 Issue 3 Pg. 361-4 (Nov 21 1986) ISSN: 0304-3940 [Print] Ireland
PMID2879266 (Publication Type: Journal Article)
Chemical References
  • Glutamates
  • Aspartic Acid
  • Glutamic Acid
  • Kynurenic Acid
Topics
  • Animals
  • Animals, Newborn
  • Aspartic Acid (physiology)
  • Brain Edema (etiology, prevention & control)
  • Brain Ischemia (drug therapy)
  • Glutamates (physiology)
  • Glutamic Acid
  • Hypoxia, Brain (drug therapy)
  • Kynurenic Acid (therapeutic use)
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: