The effect of anti-inflammatory and rheumatoid disease modifying drugs on prolonged immune and non-immune inflammation in the six-day air pouch of rats.

Abstract

The six-day air pouch model of synovitis in rats was used to study the effects of non-steroidal and anti-rheumatic drugs on cell accumulation and exudate formation. Inflammation was induced in the six-day air pouch either with the non-immune irritant carrageenan or the immune irritant Bordetella pertussis. Indomethacin reduced cell accumulation and exudate formation in both models. In contrast levamisole and D-penicillamine were unable to reduce either parameter, D-penicillamine actually producing at certain times a pro-inflammatory effect. The steroid dexamethasone caused the total inhibition of inflammatory exudate formation and cell accumulation. The six-day air pouch of rats may therefore be useful for the detection of agents which inhibit chronic inflammation.

• Authors: A Y Al-Duaij, A D Sedgwick, D A Willoughby
• Journal: International journal of tissue reactions (Int J Tissue React) Vol. 8 Issue 6 Pg. 463-8 ( 1986) ISSN: 0250-0868 [Print] Switzerland
• PMID: 2878902 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Levamisole
• Dexamethasone
• Carrageenan
• Penicillamine
• Indomethacin

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Bordetella pertussis
• Carrageenan
• Dexamethasone (therapeutic use)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Indomethacin (therapeutic use)
• Inflammation (drug therapy, etiology, immunology)
• Levamisole (therapeutic use)
• Male
• Penicillamine (therapeutic use)
• Rats
• Rats, Inbred Strains
• Synovitis (drug therapy, etiology, immunology)