HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Central effects of N-allyl,N'-methyl-barbital and N-allylmethyprylon in mice.

Abstract
Pharmacological activities (hypnotic, anticonvulsant and convulsant activities, acute toxicity and pentobarbital (PB) synergism) of N-allyl,N'-methyl derivatives of barbiturates and related N-allyl substituted compounds were studied in mice. N-Allylhexobarbital (AHB), N-allylglutethimide (AGI) and N-allylmethyprylon (AMP) showed hypnotic activity. N-Allyl,N'-methyl derivatives of barbital (B), phenobarbital (PheB) and PB (AMB, AMPheB and AMPB), AHB and AMP exhibited anticonvulsant activity against pentylenetetrazol (PTZ)-induced seizures. AMP was the most potent agent among the allyl compounds tested in the protective effect against PTZ-induced seizures. N-Allyl, N'-methylallobarbital (AMAlloB) showed a weak convulsant activity at a dose of 640 mg/kg, i.p. All allyl compounds tested showed potentiation of the PB-induced sleep. AMB prolonged the PB-induced sleep 30-fold as compared with the control. These results indicate that AMB, AMP and the other N-allyl compounds possess some depressant effects on the central nervous system.
AuthorsI Yamamoto, Y Tateoka, T Kimura, F Yamazaki, K Hamajima, K Watanabe, I K Ho
JournalResearch communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 54 Issue 2 Pg. 191-9 (Nov 1986) ISSN: 0034-5164 [Print] United States
PMID2878477 (Publication Type: Journal Article)
Chemical References
  • Allyl Compounds
  • Anticonvulsants
  • Barbiturates
  • Central Nervous System Depressants
  • Convulsants
  • Piperidones
  • N-allylmethyprylon
Topics
  • Allyl Compounds (pharmacology)
  • Animals
  • Anticonvulsants (pharmacology)
  • Barbiturates (pharmacology)
  • Brain (drug effects)
  • Central Nervous System Depressants (pharmacology)
  • Convulsants (pharmacology)
  • Male
  • Mice
  • Mice, Inbred Strains
  • Piperidones (analogs & derivatives, pharmacology)
  • Sleep (drug effects)
  • Structure-Activity Relationship

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: