Induction of hepatic tumors in rats by senkirkine and symphytine.
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| Abstract |
The carcinogenicity of the pyrrolizidine alkaloids senkirkine and symphytine was studied in male inbred ACI rats. Animals were divided into 3 groups: Group I received ip injections of freshly prepared senkirkine at a dose of 10% of the median lethal dose (LD50) twice weekly for 4 weeks and then once a week for 52 weeks. Group II received ip injections of symphytine at a dose of 10% of the LD50 by the same injection schedule as in group I. The control group was given ip injections of a 0.9% NaCl solution following the same injection schedule as in experimental groups. All group I rats survived for more than 290 days after the start of injections, and 9 of 20 rats developed liver cell adenoma. All group II animals survived for more than 330 days after the start of injections. Of 20 rats, 4 had liver tumors, 3 had hemangioendothelial sarcomas, and 1 had liver cell adenoma. The hemangioendothelial sarcomas showed metastasis in the lungs of 2 rats. The control group had no liver tumors.
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| Authors | I Hirono, M Haga, M Fujii, S Matsuura, N Matsubara, M Nakayama, T Furuya, M Hikichi, H Takanashi, E Uchida, S Hosaka, I Ueno |
| Journal | Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 63 Issue 2 Pg. 469-72 (Aug 1979) ISSN: 0027-8874 [Print] United States |
| PMID | 287835 (Publication Type: Comparative Study, Journal Article) |
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