Metabolic effects of radiation induced rat insulinoma at pancreatic, hepatic and subscapular transplantation sites.

Abstract

Metabolic effects of 3 different sites of transplantation of cultured tumour cells from a radiation induced insulinoma (28 X 10(6) viable cells per rat) were examined in 15-18 weeks old male NEDH rats. Subscapular implantation consistently produced a highly vascularised encapsulated tumour associated with hyperinsulinaemia, hyperphagia and hypoglycaemia by 21 days, which progressed to fatal neuroglycopaenic coma at 37 +/- 3 days (mean +/- SEM). Implantation of tumour cells into the hepatic portal vein resulted in a multilobular hepatic tumour in two out of nine rats, with hyperinsulinaemia and fatal hypoglycaemia by 49-54 days. Irregularities of glucose homeostasis were observed in a further three rats by 62 days. Intrapancreatic implantation consistently produced a similar tumour to that observed at the subscapular site. Implantation into the pancreas produced the most rapid onset of hyperinsulinaemia, hyperphagia and hypoglycaemia, with survival for only 28 +/- 3 days. The results demonstrate an important effect of transplantation site on the function and metabolic consequences of the NEDH rat insulinoma.

• Authors: P R Flatt, C J Bailey, C Gray, S K Swanston-Flatt
• Journal: Comparative biochemistry and physiology. A, Comparative physiology (Comp Biochem Physiol A Comp Physiol) Vol. 85 Issue 1 Pg. 183-6 ( 1986) ISSN: 0300-9629 [Print] England
• PMID: 2876815 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Insulin

Topics

• Adenoma, Islet Cell (physiopathology)
• Animals
• Blood Glucose (analysis)
• Body Weight
• Feeding Behavior
• Insulin (blood)
• Insulinoma (pathology, physiopathology)
• Male
• Neoplasm Transplantation
• Neoplasms, Radiation-Induced (pathology, physiopathology)
• Pancreatic Neoplasms (pathology, physiopathology)
• Rats
• Rats, Inbred Strains