Abstract |
Patients with active Graves' disease almost constantly show phenotypic alterations of T lymphocytes, such as an increase of "activated" cells recognized by various surface markers (e.g. la antigens). Such alterations are present in a certain number of apparently cured patients. The data herein reported refer to 25 patients with Graves' disease in clinical remission, in whom we have attempted to correlate T cell subset imbalances, the presence of thyroid-stimulating antibodies (TSAb) and the outcome of the subsequent relapse. The results obtained show a significant association between TSAb and the increase of la-positive T cells: no relationship was found between TSAb and other T lymphocyte subsets. One-year clinical follow-up of the patients enabled us to see relapses of hyperthyroidism in only two patients, who had shown in the first control both TSAb positivity and increased la-positive T cells. These results, in our opinion, suggest a role of la antigens expression on T lymphocytes in the clinical course of Graves' disease.
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Authors | M Bagnasco, E Macchia, G Ciprandi, M Caria, G F Fenzi |
Journal | Journal of endocrinological investigation
(J Endocrinol Invest)
Vol. 9
Issue 3
Pg. 217-21
(Jun 1986)
ISSN: 0391-4097 [Print] Italy |
PMID | 2876022
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Surface
- Histocompatibility Antigens Class II
- Immunoglobulin G
- Immunoglobulins, Thyroid-Stimulating
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Topics |
- Antigens, Surface
(immunology)
- Female
- Graves Disease
(immunology)
- Histocompatibility Antigens Class II
(immunology)
- Humans
- Immunoglobulin G
(analysis)
- Immunoglobulins, Thyroid-Stimulating
- Male
- Middle Aged
- Phenotype
- Recurrence
- T-Lymphocytes
(classification)
- Thyroid Gland
(immunology)
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