Abstract |
Prophylactic Action of Hexamethonium, Trimethaphan, and Mecamylamine against Diisopropyl Fluorophosphate Poisoning in Mice. Chiou, G. C. Y., Chang, W. T. S., and Aimoto, T. (1986). Fund. Appl. Toxicol. 6, 35-43. Hexamethonium, trimethaphan, and mecamylamine are ganglionic blockers which can reduce acetylcholine (ACh) release presynaptically. All these agents are capable of protecting mice from diisopropyl fluorophosphate ( DFP) intoxication by prolonging the latent period of death or by completely preventing death. Combinations of these agents with 2-pyridine aldoxime methochloride (2-PAM) (50 mg/kg) improved prophylactic action even further. These results indicate that reduction of ACh release presynaptically plus neutralization of organophosphates with 2-PAM could be an effective way to reduce mortality in patients exposed to organophosphorus poisons.
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Authors | G C Chiou, W T Chang, T Aimoto |
Journal | Fundamental and applied toxicology : official journal of the Society of Toxicology
(Fundam Appl Toxicol)
Vol. 6
Issue 1
Pg. 35-43
(Jan 1986)
ISSN: 0272-0590 [Print] United States |
PMID | 2872135
(Publication Type: Journal Article)
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Chemical References |
- Ganglionic Blockers
- Hexamethonium Compounds
- Pralidoxime Compounds
- Isoflurophate
- Mecamylamine
- Trimethaphan
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Topics |
- Animals
- Behavior, Animal
(drug effects)
- Ganglionic Blockers
(pharmacology)
- Hexamethonium Compounds
(pharmacology)
- Isoflurophate
(antagonists & inhibitors, poisoning)
- Lethal Dose 50
- Male
- Mecamylamine
(pharmacology)
- Mice
- Mice, Inbred ICR
- Pralidoxime Compounds
(pharmacology)
- Trimethaphan
(pharmacology)
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