Acute hemodynamic and metabolic effects of ICI 118,587 (Corwin), a selective partial beta 1 agonist, in patients with dilated cardiomyopathy.

Abstract

The effects of acute intravenous administration of ICI 118,587 (Corwin), a partial beta 1 agonist, were studied in nine patients with dilated cardiomyopathy and symptomatic congestive heart failure. Hemodynamic and metabolic parameters were measured using Swan-Ganz, arterial, and coronary sinus catheters. Repeated doses of Corwin produced no significant change in left ventricular performance, while a trend towards decreased blood pressure and stroke work was seen. No change occurred in coronary sinus blood flow, transmyocardial lactate extraction, or catecholamine release. One patient had significant depression of left ventricular function with hypotension. Thus, acute infusion of Corwin produced no beneficial inotropic responses, but rather produced features suggestive of further myocardial depression.

• Authors: S J Bhatia, K Swedberg, K Chatterjee
• Journal: American heart journal (Am Heart J) Vol. 111 Issue 4 Pg. 692-6 (Apr 1986) ISSN: 0002-8703 [Print] United States
• PMID: 2869673 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Agonists
• Catecholamines
• Lactates
• Propanolamines
• Xamoterol

Topics

• Adrenergic beta-Agonists (pharmacology, therapeutic use)
• Adult
• Aged
• Cardiomyopathy, Dilated (drug therapy, metabolism, physiopathology)
• Catecholamines (metabolism)
• Coronary Circulation (drug effects)
• Female
• Hemodynamics (drug effects)
• Humans
• Lactates (metabolism)
• Male
• Middle Aged
• Myocardium (metabolism)
• Propanolamines (pharmacology, therapeutic use)
• Xamoterol