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The tremorolytic action of beta-adrenoceptor blockers in essential, physiological and isoprenaline-induced tremor is mediated by beta-adrenoceptors located in a deep peripheral compartment.

Abstract
The effects of intravenous propranolol 100 micrograms kg-1, sotalol 500 micrograms kg-1, timolol 7.8 micrograms kg-1, atenolol 125 micrograms kg-1 and placebo on essential, physiological and isoprenaline-induced tremor were studied. These beta-adrenoceptor blocker doses produced equal reduction of standing-induced tachycardia in essential tremor patients. Atenolol produced significantly less reduction of essential and isoprenaline-induced tremor than the non-selective drugs, confirming the importance of beta 2-adrenoceptor blockade in these effects. Propranolol and sotalol produced equal maximal inhibition of isoprenaline-induced tremor but propranolol was significantly more effective in reducing essential tremor. The rate of development of the tremorolytic effect was similar in essential, physiological and isoprenaline-induced tremors but all tremor responses developed significantly more slowly than the heart rate responses. It is proposed that these results indicate that the tremorolytic activity of beta-adrenoceptor blockers in essential, physiological and isoprenaline-induced tremor is exerted via the same beta 2-adrenoceptors located in a deep peripheral compartment which is thought to be in the muscle spindles.
AuthorsB Abila, J F Wilson, R W Marshall, A Richens
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 20 Issue 4 Pg. 369-76 (Oct 1985) ISSN: 0306-5251 [Print] England
PMID2866785 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Receptors, Adrenergic, beta
  • Isoproterenol
Topics
  • Adrenergic beta-Antagonists (pharmacology)
  • Adult
  • Aged
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Isoproterenol
  • Male
  • Middle Aged
  • Receptors, Adrenergic, beta (drug effects)
  • Tremor (chemically induced, prevention & control)

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