Abstract |
The effects of intravenous propranolol 100 micrograms kg-1, sotalol 500 micrograms kg-1, timolol 7.8 micrograms kg-1, atenolol 125 micrograms kg-1 and placebo on essential, physiological and isoprenaline-induced tremor were studied. These beta- adrenoceptor blocker doses produced equal reduction of standing-induced tachycardia in essential tremor patients. Atenolol produced significantly less reduction of essential and isoprenaline-induced tremor than the non-selective drugs, confirming the importance of beta 2-adrenoceptor blockade in these effects. Propranolol and sotalol produced equal maximal inhibition of isoprenaline-induced tremor but propranolol was significantly more effective in reducing essential tremor. The rate of development of the tremorolytic effect was similar in essential, physiological and isoprenaline-induced tremors but all tremor responses developed significantly more slowly than the heart rate responses. It is proposed that these results indicate that the tremorolytic activity of beta- adrenoceptor blockers in essential, physiological and isoprenaline-induced tremor is exerted via the same beta 2-adrenoceptors located in a deep peripheral compartment which is thought to be in the muscle spindles.
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Authors | B Abila, J F Wilson, R W Marshall, A Richens |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 20
Issue 4
Pg. 369-76
(Oct 1985)
ISSN: 0306-5251 [Print] England |
PMID | 2866785
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Receptors, Adrenergic, beta
- Isoproterenol
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Topics |
- Adrenergic beta-Antagonists
(pharmacology)
- Adult
- Aged
- Female
- Heart Rate
(drug effects)
- Humans
- Isoproterenol
- Male
- Middle Aged
- Receptors, Adrenergic, beta
(drug effects)
- Tremor
(chemically induced, prevention & control)
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