Prophylactic phenoxybenzamine in the prevention of postoperative retention of urine after vaginal repair: a prospective randomized double-blind trial.

Abstract

To investigate the effect of prophylactic phenoxybenzamine on the bladder emptying after vaginal repair operations, 41 consecutive patients, who underwent the Manchester operation or an anterior + posterior repair because of genital descensus, were allocated at random to either prophylactic phenoxybenzamine (PBZ-group) or placebo treatment in the postoperative course. Prophylactic phenoxybenzamine was found to produce an improved emptying function of the bladder, leading to a statistically significant reduced number of acute urinary retentions (P = 0.029), decreased time until spontaneous voiding (P = 0.026) and reduced volume of residual urine (P = 0.018). Furthermore, a reduced incidence of urinary tract infections was found in the PBZ-group. Prophylactic phenoxybenzamine treatment is recommended as an alternative to routine bladder drainage in preventing urinary retention following vaginal repair operations for genital descensus.

• Authors: G Lose, P Lindholm
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 23 Issue 4 Pg. 315-20 (Sep 1985) ISSN: 0020-7292 [Print] United States
• PMID: 2866119 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Phenoxybenzamine

Topics

• Adult
• Aged
• Double-Blind Method
• Female
• Humans
• Middle Aged
• Phenoxybenzamine (therapeutic use)
• Postoperative Complications (prevention & control)
• Urinary Incontinence (etiology)
• Urinary Tract Infections (etiology)
• Urination Disorders (prevention & control)
• Uterine Prolapse (surgery)
• Vagina (surgery)