The protection given by pilus and whole cell vaccines of Bacteroides nodosus strain 198 against ovine foot-rot induced by strains of different serogroups.

Abstract

A highly purified pilus vaccine prepared from cells of Bacteroides nodosus strain 198 provided a high level of protection against homologous challenge and small, not statistically significant, levels of protection against challenge with 4 other strains each from different serogroups. In a second experiment, a partially purified pilus vaccine from strain 198 induced significant immunity to 1 of 4 heterologous strains which were different from those used in the first experiment. In a third experiment a strain 198 whole cell vaccine produced significant immunity against 3 of 6 heterologous strains used in the first 2 experiments. There was no obvious relationship between the colony type, degree of piliation and level of cross-protection obtained against a particular strain. The results provide further evidence that immunogens associated with, but distinct from, the pilus are involved in cross-protection and that cross-protective antigens are common to some, but not all, strains.

• Authors: D J Stewart, B L Clark, J E Peterson, D L Emery, E F Smith, D A Griffiths, I J O'Donnell
• Journal: Australian veterinary journal (Aust Vet J) Vol. 62 Issue 5 Pg. 153-9 (May 1985) ISSN: 0005-0423 [Print] England
• PMID: 2864040 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Bacterial Vaccines

Topics

• Agglutination Tests (veterinary)
• Animals
• Antibodies, Bacterial (analysis)
• Antibody Specificity
• Bacterial Vaccines (immunology)
• Bacteroides (immunology, ultrastructure)
• Female
• Fimbriae, Bacterial (immunology)
• Foot Rot (immunology, prevention & control)
• Male
• Sheep
• Sheep Diseases (immunology, prevention & control)