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Randomised controlled trial of azathioprine withdrawal in autoimmune chronic active hepatitis.

Abstract
To assess the value of azathioprine in the maintenance therapy of autoimmune chronic active hepatitis a controlled trial of azathioprine withdrawal was carried out in 50 patients who had been maintained in remission on a combination of azathioprine and prednisolone. The patients were randomly allocated to remain on combination therapy (23) or to discontinue azathioprine (27). These 2 groups were comparable at the start of the study. Over a follow-up period of up to 3 years, biochemical and histological relapse occurred in 8 patients in the azathioprine-withdrawal group but in only 1 patient in the combination-therapy group. Cumulative probability of relapse was 32% among the patients in the withdrawal group, compared with 6.0% for those in the combination group.
AuthorsA J Stellon, J E Hegarty, B Portmann, R Williams
JournalLancet (London, England) (Lancet) Vol. 1 Issue 8430 Pg. 668-70 (Mar 23 1985) ISSN: 0140-6736 [Print] England
PMID2858619 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Prednisolone
  • Azathioprine
Topics
  • Adult
  • Aged
  • Autoimmune Diseases (drug therapy)
  • Azathioprine (administration & dosage, therapeutic use)
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Female
  • Hepatitis, Chronic (drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Prednisolone (administration & dosage, therapeutic use)
  • Random Allocation

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