Cultured neurofibromatosis tumor fibroblasts lack beta-adrenergic receptors.

Abstract

Beta-adrenergic receptors on cultured neurofibromatosis (NF) skin and tumor fibroblasts were characterized by a radioligand binding assay using (-)-125I-iodocyanopindolol (ICYP), a potent beta-antagonist. NF tumor fibroblasts had a very low density of beta-adrenergic receptors (0-450 binding sites/cell) when compared to fibroblasts obtained from a healthy skin area of NF patients or from healthy controls (average 1,800 binding sites/cell). The apparently low binding of ICYP to the NF tumor fibroblasts can be an expression of an alteration in the structure or function of the plasma membrane.

• Authors: T Kaila, R Penttinen, J Peltonen
• Journal: Neurofibromatosis (Neurofibromatosis) Vol. 1 Issue 1 Pg. 37-42 ( 1988) ISSN: 1010-5662 [Print] Switzerland
• PMID: 2856202 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Adrenergic, beta
• Iodocyanopindolol
• Pindolol

Topics

• Fibroblasts (metabolism, pathology)
• Humans
• Iodocyanopindolol
• Neurofibromatosis 1 (metabolism)
• Pindolol (analogs & derivatives, metabolism)
• Receptors, Adrenergic, beta (metabolism)
• Skin Neoplasms (metabolism)
• Tumor Cells, Cultured