HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A multicentre study on LMW-heparin effectiveness in preventing postsurgical thrombosis.

Abstract
A multicentric study was carried out involving six italian departments of general surgery to assess the efficacy of a low molecular weight (LMW) heparin called Fluxum compared to standard calcium heparin in low doses for prevention of postoperative thromboembolic complications (deep vein thrombosis and pulmonary embolism). 610 patients were treated; 308 (50.5%) of whom were treated with Fluxum at doses of 4,000 or 8,000 I.U. Axa once a day by subcutaneous injection and 302 (49.5%) with heparin calcium at doses of 5,000 I.U. two or three times a day by subcutaneous injection. We observed a total of 29 deep vein thrombosis (4.7%); 10 (3.2%) from the group treated with LMW heparin and 19 (6.3%) from the comparative group. During the study 4 (0.65%) pulmonary embolism were found, 1 (0.32%) in the group treated with LMW heparin and 3 (1%) in the group treated with calcium heparin. None serious hemorrhagic accident was reported during the study. The antithrombotic prophy laxis carried out with Fluxum was on the whole better tolerated than the treatment of the other group, registering a lower frequency of hematomas at the injection and surgical wound sites.
AuthorsS Verardi, C U Casciani, E Nicora, F Forzano, A Origone, I Valle, G Catania, G Salanitri, P Salcuni, M Azzarone
JournalInternational angiology : a journal of the International Union of Angiology (Int Angiol) 1988 Jul-Sep Vol. 7 Issue 3 Suppl Pg. 19-24 ISSN: 0392-9590 [Print] Italy
PMID2850322 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Multicenter Study)
Chemical References
  • Heparin, Low-Molecular-Weight
  • calcium heparin
  • Heparin
Topics
  • Female
  • Heparin (therapeutic use)
  • Heparin, Low-Molecular-Weight (therapeutic use)
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Postoperative Complications (prevention & control)
  • Pulmonary Embolism (prevention & control)
  • Thrombophlebitis (prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: