Abstract |
It is generally accepted that fibrotic lung diseases are mediated by macrophage-derived cytokines. We investigated the release of the monokine tumor necrosis factor-alpha (TNF) from blood monocytes in a group of 66 coal miners and 12 non-dust-exposed individuals. Twenty-seven miners had simple Coal Workers' Pneumoconiosis (CWP). Control miners (n = 39) were matched with respect to age, years underground, and smoking. Monocytes were assayed for TNF release, spontaneously or in response to soluble ( endotoxin) or particulate ( coal mine dust, silica) stimulation. TNF was measured with a TNF-specific ELISA. Monocytes of all subjects responded to stimulants by the release of TNF. Dust-exposed controls' monocytes revealed higher TNF release as compared to normal controls. The greatest discriminator between control miners and cases (CWP) was coal mine dust-induced TNF release. Interestingly, the largest difference was observed between controls and those cases with a small number of opacities (0/1, 1/0, 1/1, and 1/2), giving an odds ratio of 6.3 to find an individual with a "high" dust-induced TNF release in the patient group.
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Authors | P J Borm, N Palmen, J J Engelen, W A Buurman |
Journal | The American review of respiratory disease
(Am Rev Respir Dis)
Vol. 138
Issue 6
Pg. 1589-94
(Dec 1988)
ISSN: 0003-0805 [Print] United States |
PMID | 2849351
(Publication Type: Journal Article)
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Chemical References |
- Dust
- Lipopolysaccharides
- Tumor Necrosis Factor-alpha
- Silicon Dioxide
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Topics |
- Coal Mining
- Dust
(adverse effects)
- Humans
- Lipopolysaccharides
(pharmacology)
- Monocytes
(metabolism)
- Pneumoconiosis
(etiology, metabolism)
- Reference Values
- Silicon Dioxide
(adverse effects)
- Stimulation, Chemical
- Tumor Necrosis Factor-alpha
(metabolism)
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