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Spontaneous and stimulated release of tumor necrosis factor-alpha (TNF) from blood monocytes of miners with coal workers' pneumoconiosis.

Abstract
It is generally accepted that fibrotic lung diseases are mediated by macrophage-derived cytokines. We investigated the release of the monokine tumor necrosis factor-alpha (TNF) from blood monocytes in a group of 66 coal miners and 12 non-dust-exposed individuals. Twenty-seven miners had simple Coal Workers' Pneumoconiosis (CWP). Control miners (n = 39) were matched with respect to age, years underground, and smoking. Monocytes were assayed for TNF release, spontaneously or in response to soluble (endotoxin) or particulate (coal mine dust, silica) stimulation. TNF was measured with a TNF-specific ELISA. Monocytes of all subjects responded to stimulants by the release of TNF. Dust-exposed controls' monocytes revealed higher TNF release as compared to normal controls. The greatest discriminator between control miners and cases (CWP) was coal mine dust-induced TNF release. Interestingly, the largest difference was observed between controls and those cases with a small number of opacities (0/1, 1/0, 1/1, and 1/2), giving an odds ratio of 6.3 to find an individual with a "high" dust-induced TNF release in the patient group.
AuthorsP J Borm, N Palmen, J J Engelen, W A Buurman
JournalThe American review of respiratory disease (Am Rev Respir Dis) Vol. 138 Issue 6 Pg. 1589-94 (Dec 1988) ISSN: 0003-0805 [Print] United States
PMID2849351 (Publication Type: Journal Article)
Chemical References
  • Dust
  • Lipopolysaccharides
  • Tumor Necrosis Factor-alpha
  • Silicon Dioxide
Topics
  • Coal Mining
  • Dust (adverse effects)
  • Humans
  • Lipopolysaccharides (pharmacology)
  • Monocytes (metabolism)
  • Pneumoconiosis (etiology, metabolism)
  • Reference Values
  • Silicon Dioxide (adverse effects)
  • Stimulation, Chemical
  • Tumor Necrosis Factor-alpha (metabolism)

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