Detection of DNA transcripts of measles genes in multiple sclerosis brain tissue by transfection.

Abstract

Transfection studies on DNA obtained from 16 multiple sclerosis (MS) and 13 non-MS brain tissues suggested that 3/16 (19%) MS and 3/13 (23%) non-MS samples contained contaminating measles virus double-stranded RNA, and that 6/16 (38%) MS and 0/13 non-MS samples contained DNA transcripts of measles genes. It is argued that the DNA transcripts most probably originated from dual retrovirus and measles infections in the subjects.

• Authors: L W Greenham, D Hicks, S Smith
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 85 Issue 1 Pg. 55-65 (May 1988) ISSN: 0022-510X [Print] Netherlands
• PMID: 2838584 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Viral

Topics

• Adult
• Aged
• Brain Chemistry
• DNA, Viral (analysis, genetics)
• Female
• Humans
• Infant
• Infant, Newborn
• Male
• Measles virus (genetics)
• Middle Aged
• Multiple Sclerosis (microbiology)
• Retroviridae Infections (microbiology)
• Transfection