Photoradiation in the treatment of recurrent breast carcinoma.

Abstract

Photoradiation, with the use of hematoporphyrin derivative (Hpd) activated by visible light in the red region of the spectrum, was an effective treatment for controlling local and regional chest wall recurrences of breast carcinoma. With sufficient time between iv injection of the drug and local activation with red light, cutaneous and subcutaneous masses were treated effectively without undue damage to overlying and adjacent skin. This high therapeutic ratio resulted from the ability to Hpd to accumulate and/or to be retained to a higher degree in malignant tissue than in many normal tissues. This technique can be used as a primary treatment or upon tumor recurrence following conventional modalities such as surgery, chemotherapy, and radiation therapy.

• Authors: T J Dougherty, G Lawrence, J H Kaufman, D Boyle, K R Weishaupt, A Goldfarb
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 62 Issue 2 Pg. 231-7 (Feb 1979) ISSN: 0027-8874 [Print] United States
• PMID: 283259 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hematoporphyrins

Topics

• Breast Neoplasms (drug therapy)
• Female
• Hematoporphyrins (administration & dosage, adverse effects, therapeutic use)
• Humans
• Photochemistry
• Photosensitivity Disorders (chemically induced)
• Recurrence
• Remission, Spontaneous
• Skin Neoplasms (drug therapy)
• Thorax