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Progression of dermatofibrosarcoma protuberans to malignant fibrous histiocytoma: report of a case with implications for tumor histogenesis.

Abstract
A 79-year-old woman required amputation of her left leg for the control of a rapidly growing malignant fibrous histiocytoma. This tumor had developed at the precise site of repeated recurrence of a previously diagnosed dermatofibrosarcoma protuberans. Biopsy specimens from the recurrences revealed a gradual change in appearance from dermatofibrosarcoma protuberans to malignant fibrous histiocytoma.
AuthorsJ O'Dowd, P Laidler
JournalHuman pathology (Hum Pathol) Vol. 19 Issue 3 Pg. 368-70 (Mar 1988) ISSN: 0046-8177 [Print] United States
PMID2831136 (Publication Type: Case Reports, Journal Article)
Topics
  • Aged
  • Biopsy
  • Female
  • Fibrosarcoma (pathology)
  • Histiocytoma, Benign Fibrous (pathology)
  • Humans
  • Immunohistochemistry
  • Microscopy, Electron
  • Neoplasm Recurrence, Local

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