Heterologous flavivirus infection-enhancing antibodies in sera of Nigerians.

Abstract

Human sera collected from Nigerians were examined for plaque reduction neutralizing and infection-enhancing antibodies against dengue 2, yellow fever, and West Nile viruses. Neutralization tests showed that 17 of 19 sera contained flavivirus neutralizing antibody; 11 were positive to all 3 viruses, 5 to dengue and yellow fever, and 1 to dengue virus only. Two sera had no detectable neutralizing antibody to any of the flaviviruses. Enhancement assays showed that 17 flavivirus neutralizing antibody-positive sera contained infection-enhancing antibodies to dengue 2, and 16 had antibody to yellow fever. Although 11 sera were positive for West Nile neutralizing antibody, 17 enhanced this virus. Heterologous infection-enhancing antibody titers were lower than the homologous ones. Broadly reacting sera and those with high neutralizing antibody titers produced the highest infection-enhancing antibody titers.

• Authors: A Fagbami, S B Halstead, N Marchette, K Larsen
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 38 Issue 1 Pg. 205-7 (Jan 1988) ISSN: 0002-9637 [Print] United States
• PMID: 2829637 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Viral

Topics

• Antibodies, Viral (analysis)
• Dengue Virus (immunology)
• Fetal Blood (immunology)
• Flavivirus (immunology)
• Humans
• Infant, Newborn
• Neutralization Tests
• Nigeria
• Togaviridae Infections (epidemiology, immunology)
• West Nile virus (immunology)
• Yellow fever virus (immunology)