Abstract |
1. Active electrolyte transport was examined in erythrocytes from women in the second and third trimesters of pregnancy and post partum, and compared with that in ovulating women. 2. There was a significant reduction in intracellular sodium ([Na]i) and increase in intracellular potassium ([K]i) in pregnancy with a return towards normal values in the post-partum period. 3. Maximum specific ouabain binding [number of Na+,K+- adenosine triphosphatase (Na+, K+- ATPase) units] was increased by 70% in pregnancy and returned slowly towards normal values post partum. 4. Na+,K+- ATPase activity as determined by ouabain-sensitive 86Rb influx in artificial media was also increased in pregnancy by 13%. It returned towards normal post partum. 5. The increases in Na+,K+- ATPase in pregnancy were not closely related to the concomitant increases in aldosterone or cholesterol nor to reticulocytosis and were not affected by 7 days of high (greater than 250 mmol/day) or low (less than 50 mmol/day) sodium intake.
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Authors | E D Gallery, J Rowe, M A Brown, M Ross |
Journal | Clinical science (London, England : 1979)
(Clin Sci (Lond))
Vol. 74
Issue 2
Pg. 145-50
(Feb 1988)
ISSN: 0143-5221 [Print] England |
PMID | 2827941
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Sodium, Dietary
- Ouabain
- Sodium
- Sodium-Potassium-Exchanging ATPase
- Potassium
|
Topics |
- Biological Transport, Active
(drug effects)
- Erythrocytes
(metabolism)
- Female
- Humans
- Ouabain
(pharmacology)
- Postpartum Period
(blood)
- Potassium
(blood)
- Pregnancy
(blood)
- Pregnancy Trimester, First
- Pregnancy Trimester, Second
- Pregnancy Trimester, Third
- Sodium
(blood)
- Sodium, Dietary
(administration & dosage)
- Sodium-Potassium-Exchanging ATPase
(blood)
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