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Evidence for a receptor-mediated endocytosis of Alu I in Chinese hamster ovary cells.

Abstract
Pretreatment of Chinese hamster ovary cells with proteases or with NaN3 leads to less chromosomal aberrations when the cells are posttreated with Alu I compared to the treatment of cells with Alu I alone. The same result is obtained when the cells are treated with Alu I at 0 degree C instead of 37 degrees C. The cells recover from the protease treatment when they are kept in medium before treatment with Alu I. These results are interpreted to mean that Alu I is bound by surface receptors and that the Alu I-receptor complexes are internalized by an energy-dependent endocytotic process.
AuthorsV Vasudev, G Obe
JournalMutation research (Mutat Res) Vol. 197 Issue 1 Pg. 109-16 (Jan 1988) ISSN: 0027-5107 [Print] Netherlands
PMID2827015 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Azides
  • Receptors, Cell Surface
  • Sodium Azide
  • DNA Restriction Enzymes
  • endodeoxyribonuclease AluI
  • Deoxyribonucleases, Type II Site-Specific
  • Peptide Hydrolases
Topics
  • Animals
  • Azides (toxicity)
  • Cell Line
  • Chromosome Aberrations
  • Cricetinae
  • Cricetulus
  • DNA Restriction Enzymes (metabolism)
  • Deoxyribonucleases, Type II Site-Specific
  • Endocytosis
  • Female
  • Ovary
  • Peptide Hydrolases (pharmacology)
  • Receptors, Cell Surface (metabolism)
  • Sodium Azide

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