The purpose of this study is to review the pertinent literature on the incidence, methods of induction and pathogenesis of ovarian
tumors of mice. Strains of mice with a high incidence of spontaneously occurring
granulosa cell tumors (gct) and tubular
adenomas (ta) are the C3HeB/Fe and C3HeB/De; strain HAN:NMRI developed Sertoli cell
tumors and (DBA x Ce)F1 hybrids had a high incidence gct. Ninety-five percent of hybrid (C57BL/6J x C3H/HeJ)F1 WxWv mice which lack germ cells develop complex tubular
adenomas. Strain LT, in which a high percentage of ovarian ova develop parthenogenetically, develops has a high incidence of
teratomas. The use of
hormones,
castration and
transplantation of the ovaries in a number of inbred strains results in a high incidence of ovarian
tumors; in strain Maf/Sp gct and
luteomas were induced in 82%. Irradiation with gamma rays produced a similar incidence of ovarian
tumors in (C57L x A)F1 hybrids. The chemical inducing the highest incidence (92%) of ovarian
tumors of mice is 9,10 Dimethyl 1,2
benzanthracene (DMBA). Recently,
4-Vinylcyclohexene was shown to induce a high incidence of ovarian
tumors. A number of rare ovarian
tumors were reported. Described are five
androblastomas composed of either Leydig or Sertoli cells or a combination of the two cell types and a single undifferentiated
androblastoma. Seven
teratomas were described, three of which contained large amounts of neural tissue; another was classified as a
teratoma with a parieto-visceral yolk-sac
carcinoma component.