Coxsackie virus infection in association with heart affection in man.

Abstract

The frequency of actual infections by selected types of coxsackie virus (B1-B6, A7, A9) has been followed up in adult patients hospitalized for reason of heart disease. Criteria of actual coxsackie virus infection have been defined, including a significant rise of titer of virus neutralizing antibodies and/or presence of virus-specific IgM antibodies. An actual coxsackie virus infection has been found in 71 (46.3%) out of 153 patients. Most frequently coxsackie B1 virus infection (24 times) and B4 (17 times) could be proved. In sera of patients with actual coxsackie virus infection, a higher proportion of infection with some types of coxsackie viruses, along with the presence of antibodies against a larger number of coxsackie virus types has been found, as compared to sera from patients without actual coxsackie virus infection, and/or, in sera of healthy blood donors (control group). The role of repeated infections with different types of coxsackie virus in the etiology of heart disease has been discussed.

• Authors: A Petrovicová, J Cervenka, A Egnerová
• Journal: Journal of hygiene, epidemiology, microbiology, and immunology (J Hyg Epidemiol Microbiol Immunol) Vol. 31 Issue 3 Pg. 251-7 ( 1987) ISSN: 0022-1732 [Print] Czech Republic
• PMID: 2824602 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Immunoglobulin M

Topics

• Antibodies, Viral (analysis)
• Coxsackievirus Infections (complications)
• Enterovirus B, Human (immunology)
• Heart Diseases (etiology)
• Humans
• Immunoglobulin M (analysis)
• Neutralization Tests