[Fluoroquinolones and their importance in modern chemotherapy of infectious diseases].

Abstract

Experimental and clinical data on antibacterial drugs belonging to fluorine derivatives of quinolone carboxylic acid (quinolones of the third generation) were summarized. Brief characteristics of their antibacterial activity and experimental data on chemotherapeutic activity of pefloxacin, a fluoroquinolone on models of septicopyemia and meningoencephalitis in experiments with mice infected by P. aeruginosa, Staphylococcus and Klebsiella are presented. High efficacy of pefloxacin was shown and its advantages over dioxidine and gentamicin on the model of meningoencephalitis were revealed. The main indications to the use of fluoroquinolones, possible adverse reactions and contraindications to the use of the drugs of that group are described.

• Authors: E N Padeĭskaia
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 34 Issue 7 Pg. 514-21 (Jul 1989) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Ftor-khinolony i ikh znachenie v sovremennoĭ khimioterapii infektsionnykh zabolevaniĭ.
• PMID: 2818083 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• 4-Quinolones
• Anti-Infective Agents

Topics

• 4-Quinolones
• Animals
• Anti-Infective Agents (adverse effects, therapeutic use)
• Bacterial Infections (drug therapy)
• Mice
• Structure-Activity Relationship