Urine-TPA (tissue polypeptide antigen), flow cytometry and cytology as markers for tumor invasiveness in urinary bladder carcinoma.

Abstract

Urine-Tissue Polypeptide Antigen (U-TPA) was measured in 81 patients with a previously diagnosed bladder carcinoma. U-TPA was elevated in 74% of the patients with invasive bladder cancer as compared to only 15% of the patients with superficial tumors. Only one patient without a tumor recurrence had an elevated U-TPA level (4%). The results were compared with cytological grading and flow-DNA measurements in a multivariate analysis with T-category as the result variable. U-TPA and grade showed each, independently, a significant relation (P much less than 0.001) to T-category whereas the result of the DNA measurements did not explain the variation in T-category when U-TPA and grade were already in the equation. For diagnostic purposes U-TPA seems to be of limited value but may serve as an indicator of tumor recurrence in bladder cancer patients.

• Authors: B E Carbin, P Ekman, P Eneroth, B Nilsson
• Journal: Urological research (Urol Res) Vol. 17 Issue 5 Pg. 269-72 ( 1989) ISSN: 0300-5623 [Print] Germany
• PMID: 2815427 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• Peptides
• Tissue Polypeptide Antigen

Topics

• Antigens, Neoplasm (urine)
• Biomarkers, Tumor (urine)
• Carcinoma, Transitional Cell (immunology)
• Flow Cytometry
• Humans
• Neoplasm Recurrence, Local (immunology)
• Peptides (urine)
• Tissue Polypeptide Antigen
• Urinary Bladder Neoplasms (immunology)