Brenner tumor of the ovary: immunoanalysis of steroidogenic enzymes in 23 cases.

Abstract

Immunohistochemical analysis of cytochromes P-450 aromatase and P-450 17 alpha-hydroxylase, which catalyze the production of estrogens and androgens, respectively, was performed for 23 cases of ovarian Brenner tumor. Immunoreactivity for P-450 aromatase was observed in the epithelial cells of the tumor distinctly in two cases and faintly in four cases, while immunoreactivity for P-450 17 alpha-hydroxylase was seen in two cases. No immunoreactivity was observed in the stromal cells of the tumors, nor were luteinized cells observed in the cases examined. No correlation was observed between the immunoreactivity of cytochromes P-450 in the epithelial cells of the tumor and endometrial abnormalities. These findings, together with a review of the literature, suggest that the usual Brenner tumor is not associated with specific steroidogenesis. Rare massive Brenner tumors may, however, be capable of androgenic or estrogenic activity.

• Authors: H Sasano, E S Wargotz, S G Silverberg, J I Mason, E R Simpson
• Journal: Human pathology (Hum Pathol) Vol. 20 Issue 11 Pg. 1103-7 (Nov 1989) ISSN: 0046-8177 [Print] United States
• PMID: 2807272 (Publication Type: Journal Article)

Chemical References

• Steroid Hydroxylases
• Aromatase
• Steroid 17-alpha-Hydroxylase

Topics

• Aromatase (analysis)
• Corpus Luteum (enzymology)
• Epithelium (enzymology)
• Female
• Humans
• Immunohistochemistry
• Ovarian Neoplasms (enzymology, pathology)
• Steroid 17-alpha-Hydroxylase (analysis)
• Steroid Hydroxylases (analysis)