Serum distribution of iodine after oral administration of ethylenediamine dihydriodide in cattle.

Abstract

Serum concentrations of iodine were determined after cattle were given ethylenediamine dihydriodide (EDDI) orally at dosages ranging from 0.0 (placebo) to 0.77 mg/kg of body weight/day. The serum iodine concentration was correlated with the dosage of EDDI. A rate of 0.11 mg EDDI/kg/day was correlated with serum iodine concentrations (20 to 80 micrograms/dl) previously found to be effective in preventing foot rot in cattle. A linear dose-response curve that was generated could be helpful in predicting dosage of EDDI if the serum iodine concentration is known.

• Authors: J Maas, J N Berg, R G Petersen
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 50 Issue 10 Pg. 1758-9 (Oct 1989) ISSN: 0002-9645 [Print] United States
• PMID: 2802309 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ethylenediamines
• ethylenediamine
• Iodine

Topics

• Administration, Oral
• Animals
• Cattle (metabolism)
• Dose-Response Relationship, Drug
• Ethylenediamines (administration & dosage, pharmacokinetics)
• Female
• Iodine (blood)
• Male
• Regression Analysis