Abstract |
This study was undertaken to determine the susceptibility of experimentally induced Spiroplasma mirum infection in the rat to trimethoprim/sulfamethoxazole ( TMP/SMX) in combination with hyperbaric oxygen (HBO). One-day-old Fisher 344 rats were intracerebrally inoculated with the GT-48 strain of S. mirum and were exposed to regimens employed combined antibiotic and HBO treatments. The exclusive use of TMP/SMX produced a significant reduction in mortality (P less than 0.0001) and an absence of clinical signs of infection. HBO in combination with TMP/SMX showed similar effect on mortality and no evident clinical disease. The addition of HBO did result in a significant decrease in spiroplasma brain titres but was no more effective in preventing the spiroplasma-induced fatal microcystic encephalopathy than when the antibiotics were used alone. The exclusive use of HBO produced a catastrophic mortality rate in the spiroplasma-infected rats, which is contrary to the effect of HBO on conventional bacterial infections.
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Authors | F O Bastian, R A Jennings, C J Hoff |
Journal | Research in microbiology
(Res Microbiol)
Vol. 140
Issue 2
Pg. 151-8
(Feb 1989)
ISSN: 0923-2508 [Print] France |
PMID | 2799063
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Bacterial Agents
- Trimethoprim
- Sulfamethoxazole
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Topics |
- Animals
- Anti-Bacterial Agents
- Bacterial Infections
(mortality, therapy)
- Combined Modality Therapy
- Drug Therapy, Combination
(therapeutic use)
- Encephalitis
(mortality, therapy)
- Hyperbaric Oxygenation
- Rats
- Rats, Inbred F344
- Spiroplasma
- Sulfamethoxazole
(therapeutic use)
- Trimethoprim
(therapeutic use)
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