[Biorhythm study of the alpha-glycerophosphate dehydrogenase activity of the peripheral blood lymphocytes in rats with Walker carcinosarcoma].

Abstract

In the series of experiments alpha-glycerophosphate dehydrogenase activity was daily determined at the same time by cytochemical method in the peripheral lymphocyte of normal rats and those with Walker carcinosarcoma. Using an original algorithm a hierarchy of biorhythms was singled out on a computer according to the individual changes in alpha-glycerophosphate dehydrogenase activity in each rat. It was shown that tumor development resulted in the reduction of the mean level of alpha-glycerophosphate dehydrogenase activity and considerable changes in diverse rhythms. Particular attention is paid to the phase changes, which can reveal changes in phase coordination of glycerophosphate shuttle cycle components.

• Authors: L M Strigun, E N Chirkova, G G Grigor'eva, L A Gromova, M A Iakunina
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 107 Issue 6 Pg. 731-5 (Jun 1989) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Bioritmologicheskoe issledovanie aktivnosti al'fa-glitserofosfatdegidrogenazy limfotsitov perifericheskoĭ krovi krys s kartsinosarkomoĭ Uokera.
• PMID: 2790174 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Glycerolphosphate Dehydrogenase

Topics

• Animals
• Carcinoma 256, Walker (enzymology)
• Glycerolphosphate Dehydrogenase (blood)
• Lymphocytes (enzymology)
• Male
• Neoplasm Transplantation
• Periodicity
• Rats
• Seasons
• Time Factors