Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis.

Abstract

The occurrence of anti-double stranded(ds) DNA idiotype 2C10 was studied in patients with mixed connective tissue disease (MCTD) and progressive systemic sclerosis (PSS). The 2C10-idiotype was originally identified on a dsDNA-specific monoclonal antibody from a lupus-prone MRL/Mp-lpr/lpr (MRL/l) mouse, and it has been demonstrated to be present in the sera of patients with systemic lupus erythematosus (SLE) as well as MRL/l mice. This study showed that three out of ten patients with MCTD and five out of ten with PSS had higher titers of 2C10-idiotype in their sera than the normal subjects. There was a good correlation between the anti-dsDNA activities and the idiotype levels in MCTD (r = 0.85) but not in PSS (r = -0.38). These results suggest that the 2C10-idiotype-bearing antibodies acquire the dsDNA-binding activity more easily in MCTD than in PSS.

• Authors: T Kubota, Y Kanai
• Journal: The Bulletin of Tokyo Medical and Dental University (Bull Tokyo Med Dent Univ) Vol. 36 Issue 2 Pg. 13-8 (Jun 1989) ISSN: 0040-8921 [Print] Japan
• PMID: 2789110 (Publication Type: Journal Article)

Chemical References

• Antibodies, Antinuclear
• Antibodies, Monoclonal
• Immunoglobulin Idiotypes
• DNA

Topics

• Animals
• Antibodies, Antinuclear (analysis)
• Antibodies, Monoclonal
• Antibody Specificity
• Autoimmune Diseases (immunology)
• DNA (immunology)
• Humans
• Immunoglobulin Idiotypes (analysis)
• Lupus Erythematosus, Systemic (immunology)
• Mice
• Mice, Inbred Strains
• Mixed Connective Tissue Disease (immunology)
• Scleroderma, Systemic (immunology)