Abstract |
The studies were performed on Wistar rats with acute myeloblastic leukemia induced by a prolonged administration of tritiated water (370 MBq/kg/day-1; an absorbed dose--25.3 Gy) and by repeated pyrogenal injections. A reduction of the pool of polypotent hemopoietic cells (CFUs) with a simultaneous increase of their proliferative activity and a decline of their ability to self-supporting were observed in the leukemia-bearing animals. Populations of CFUdc in DC and of CFUc were reduced in all cases; their colony-forming ability was also found to decrease. All animals with leukemia showed a lowered amount of CFU-BL in the bone marrow and of CFU-TL in the thymus, although the content of these cells in the peripheral blood remained unchanged.
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Authors | K N Muksinova, L D Murzina, E N Kirillova, V S Revina |
Journal | Eksperimental'naia onkologiia
(Eksp Onkol)
Vol. 11
Issue 3
Pg. 29-32
( 1989)
ISSN: 0204-3564 [Print] Ukraine |
Vernacular Title | Krovetvornye kletki-predshestvenniki u krys porody Wistar s ostrym mieloblastnym leĭkozom. |
PMID | 2787740
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Lipopolysaccharides
- Pyrogens
- pyrogenal
- Water
- Tritium
- tritium oxide
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Topics |
- Animals
- B-Lymphocytes
(drug effects, pathology, radiation effects)
- Bone Marrow
(drug effects, pathology, radiation effects)
- Colony-Forming Units Assay
- Granulocytes
(drug effects, pathology, radiation effects)
- Hematopoietic Stem Cells
(drug effects, pathology, radiation effects)
- Leukemia, Myeloid, Acute
(etiology, pathology)
- Leukemia, Radiation-Induced
(etiology, pathology)
- Lipopolysaccharides
- Monocytes
(drug effects, pathology, radiation effects)
- Pyrogens
- Rats
- Rats, Inbred Strains
- T-Lymphocytes
(drug effects, pathology, radiation effects)
- Time Factors
- Tritium
- Water
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