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Antibodies to nuclear lamin proteins in liver disease.

Abstract
Sera of patients with autoimmune liver disease contained antibodies reactive with nuclear lamins. These antigens were identified in immunoblotting experiments, using isolated nuclei, nuclear matrices, nuclear lamina-pore complexes and purified lamins as antigen source. The lamins were, furthermore, characterized by 2-dimensional gel electrophoresis. Antibodies to nuclear lamins were found in 75 per cent of the active lupoid hepatitis cases, but not in patients with inactive disease. Anti-lamin antibodies were detected in 8 per cent of primary biliary cirrhosis sera. The autoimmune liver disease sera recognized predominantly the nuclear lamins A/C, and less frequently the lamins A/B/C or lamin B.
AuthorsJ Wesierska-Gadek, E Penner, E Hitchman, G Sauermann
JournalImmunological investigations (Immunol Invest) 1989 Jan-May Vol. 18 Issue 1-4 Pg. 365-72 ISSN: 0882-0139 [Print] England
PMID2786499 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Antinuclear
  • Laminin
Topics
  • Antibodies, Antinuclear (isolation & purification)
  • Autoimmune Diseases (immunology)
  • Hepatitis (immunology)
  • Humans
  • Laminin (immunology)
  • Liver Cirrhosis, Biliary (immunology)
  • Liver Diseases (immunology)

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