[Interleukin 2 secretion by lymphocytes of patients with squamous cell cancer of the oropharynx or larynx].

Abstract

The various strengthening influences of interleukin-2 (IL-2) on the immunological system is of intrinsic importance to tumour defense. IL-2 concentration can be measured by the determination of the IL-2 dependent CTLL cell line in a micro-Elisa-assay. The IL-2 secretion is dose dependent after stimulation with the mitogens phytohaemagglutinin A (PHA), phorbolester (PMA) or the monoclonal T cell antibody OKT3. Maximal IL-2 release is achieved by concomitant activation with phytohaemagglutinin A (PHA) and phorbolester (PMA). As controls healthy donors with low and high alcohol and cigarette consumption were used. In patients with cancer of the oropharynx, a significant reduction in the IL-2 secretion was observed when compared with the larynx cancer group or with healthy donors. This might suppose an immunological influence of the squamous cell carcinoma which grows in the oropharynx in close proximity to lymphatic cells and vessels which are numerously present in the tonsillar ring of Waldeyer.

• Authors: T P Wustrow
• Journal: Laryngo- rhino- otologie (Laryngorhinootologie) Vol. 68 Issue 2 Pg. 110-7 (Feb 1989) ISSN: 0935-8943 [Print] Germany
• Vernacular Title: Interleukin-2 Sekretion aus Lymphozyten von Patienten mit Plattenepithelkarzinomen im Oropharynx oder Larynx.
• PMID: 2784971 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-2

Topics

• Adult
• Aged
• Alcoholism (immunology)
• Carcinoma, Squamous Cell (immunology)
• Female
• Humans
• Immune Tolerance
• Interleukin-2 (biosynthesis)
• Laryngeal Neoplasms (immunology)
• Lymphocyte Activation
• Male
• Middle Aged
• Oropharyngeal Neoplasms (immunology)
• Pharyngeal Neoplasms (immunology)
• Smoking (immunology)
• T-Lymphocytes (immunology)
• Tumor Cells, Cultured (immunology)