Abstract |
Pagetoid reticulosis (PaRet) is a rare skin disease with an intraepidermal infiltrate of atypical lymphocytes. We performed phenotypic studies on two patients with classic localized PaRet ( Woringer-Kolopp disease) and one patient with the disseminated type ( Ketron-Goodman disease) and compared these with all published reports of cases; both variants show intraepidermal, highly activated, proliferating T cells with variable loss of pan-T-cell antigens, contrasting with nonactivated dermal reactive T cells. This pattern is unique among cutaneous lymphomas and can be used for diagnosis. Despite the fact that localized PaRet does not show a malignant course, recent genotypic analysis of one patient showed monoclonality. Comparable constellations are found in other diseases like lymphomatoid papulosis, which also represent monoclonal disorders of activated T cells with a benign course. To unify these seeming discrepancies, we introduce the concept of "benign cutaneous lymphomas."
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Authors | V Mielke, H H Wolff, M Winzer, W Sterry |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 125
Issue 3
Pg. 402-6
(Mar 1989)
ISSN: 0003-987X [Print] United States |
PMID | 2784302
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal
- Epidermis
(pathology)
- Female
- Humans
- Lymphoproliferative Disorders
(pathology)
- Male
- Phenotype
- Skin Diseases
(pathology)
- T-Lymphocytes
(classification, pathology)
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