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Localized and disseminated pagetoid reticulosis. Diagnostic immunophenotypical findings.

Abstract
Pagetoid reticulosis (PaRet) is a rare skin disease with an intraepidermal infiltrate of atypical lymphocytes. We performed phenotypic studies on two patients with classic localized PaRet (Woringer-Kolopp disease) and one patient with the disseminated type (Ketron-Goodman disease) and compared these with all published reports of cases; both variants show intraepidermal, highly activated, proliferating T cells with variable loss of pan-T-cell antigens, contrasting with nonactivated dermal reactive T cells. This pattern is unique among cutaneous lymphomas and can be used for diagnosis. Despite the fact that localized PaRet does not show a malignant course, recent genotypic analysis of one patient showed monoclonality. Comparable constellations are found in other diseases like lymphomatoid papulosis, which also represent monoclonal disorders of activated T cells with a benign course. To unify these seeming discrepancies, we introduce the concept of "benign cutaneous lymphomas."
AuthorsV Mielke, H H Wolff, M Winzer, W Sterry
JournalArchives of dermatology (Arch Dermatol) Vol. 125 Issue 3 Pg. 402-6 (Mar 1989) ISSN: 0003-987X [Print] United States
PMID2784302 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal
  • Epidermis (pathology)
  • Female
  • Humans
  • Lymphoproliferative Disorders (pathology)
  • Male
  • Phenotype
  • Skin Diseases (pathology)
  • T-Lymphocytes (classification, pathology)

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