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Multiplicity of spontaneous lung tumors in CD-1 mice.

Abstract
The multiplicity of the spontaneous lung tumor in CD-1 mice was investigated in 413 males from 6 different control groups of 2-year carcinogenicity studies with agrochemicals. Among a total of 152 lung tumor bearers, 95 (62.5%) were seen with 1 nodule, 36 (23.7%) with 2 nodules, and 14 (9.2%) with 3 nodules. Three males bore 4 nodules and each of 5, 7, 9 and 10 nodules was seen in one male, respectively. In one control group 20 out of 30 lung tumor bearers had 2 or more nodules presenting a significant heterogeneity among the control groups in terms of the multiplicity of lung tumor nodule.
AuthorsK Maita, M Hirano, T Harada, K Mitsumori, A Yoshida, K Takahashi, N Nakashima, T Kitazawa, A Enomoto, K Inui
JournalThe Journal of toxicological sciences (J Toxicol Sci) Vol. 14 Issue 2 Pg. 87-90 (May 1989) ISSN: 0388-1350 [Print] Japan
PMID2778856 (Publication Type: Journal Article)
Topics
  • Animals
  • Lung Neoplasms (epidemiology, veterinary)
  • Male
  • Mice
  • Mice, Inbred Strains
  • Rodent Diseases (epidemiology)

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