Abstract |
The chromatographic profiles of IgM anti-delta in 45 acute and 24 chronic delta patients were analyzed by fast protein liquid chromatography (FPLC). Predominance of 19S IgM anti-delta was observed in the sera of 100 percent of coinfected and 62% of superinfected patients. In contrast, 7S IgM anti-delta was predominant in 83% of patients with chronic hepatitis delta. The study of the chromatographic profiles of IgM anti-delta in the development of the disease showed an association between the process of chronic delta-infection and the failure of 7S IgM anti-delta monomers to form 19S pentamers. The results showed that the test for 7S and 19S IgM anti-delta could be useful for differential diagnosis of acute and chronic hepatitis delta infection and for determining the prognosis of acute delta infection.
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Authors | S O Vyazov, I N Khlopova, V V Mesyanzhinov |
Journal | Viral immunology
(Viral Immunol)
Vol. 2
Issue 2
Pg. 61-7
( 1989)
ISSN: 0882-8245 [Print] United States |
PMID | 2775432
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin M
- polymeric IgM
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Topics |
- Acute Disease
- Chromatography, High Pressure Liquid
- Chronic Disease
- Hepatitis D
(immunology)
- Humans
- Immunoglobulin M
(metabolism)
- Prognosis
- Time Factors
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