HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Monomeric (7S) and polymeric (19S) IgM anti-delta in acute and chronic delta infections.

Abstract
The chromatographic profiles of IgM anti-delta in 45 acute and 24 chronic delta patients were analyzed by fast protein liquid chromatography (FPLC). Predominance of 19S IgM anti-delta was observed in the sera of 100 percent of coinfected and 62% of superinfected patients. In contrast, 7S IgM anti-delta was predominant in 83% of patients with chronic hepatitis delta. The study of the chromatographic profiles of IgM anti-delta in the development of the disease showed an association between the process of chronic delta-infection and the failure of 7S IgM anti-delta monomers to form 19S pentamers. The results showed that the test for 7S and 19S IgM anti-delta could be useful for differential diagnosis of acute and chronic hepatitis delta infection and for determining the prognosis of acute delta infection.
AuthorsS O Vyazov, I N Khlopova, V V Mesyanzhinov
JournalViral immunology (Viral Immunol) Vol. 2 Issue 2 Pg. 61-7 ( 1989) ISSN: 0882-8245 [Print] United States
PMID2775432 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Immunoglobulin M
  • polymeric IgM
Topics
  • Acute Disease
  • Chromatography, High Pressure Liquid
  • Chronic Disease
  • Hepatitis D (immunology)
  • Humans
  • Immunoglobulin M (metabolism)
  • Prognosis
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: