[Effects of tetrodotoxin and verapamil on abnormal ventricular activity at the late stage of experimental myocardial infarction in dogs].

Abstract

An in situ experimental study of the heart has demonstrated that verapamil++ (0.3 mg/kg), administered intravenously to dogs with complete transverse heart block one day after two-step occlusion of the left descending coronary artery either produced a 15-30% drop in the incidence of abnormal ventricular activity (AVA) in some experiments, or had no effect on the latter in others. Tetrodotoxin (3 micrograms/kg) produced a 20-44% drop in AVA in all experiments. Combined administration of 0.2 mg/kg verapamil++ and 2 micrograms/kg tetrodotoxin completely suppressed AVA. At an early phase of its development (5-10 hours after the occlusion of the left descending artery), AVA was completely suppressed both by 0.3 mg/kg verapamil and 3 micrograms/kg tetrodotoxin. Mechanisms of AVA and its progress following coronary-artery occlusion in dogs are discussed.

• Authors: E P Aniukhovskiĭ, T Ivanovich, G G Beloshapko, L V Rozenshtraukh
• Journal: Kardiologiia (Kardiologiia) Vol. 29 Issue 5 Pg. 66-71 (May 1989) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie tetrodotoksina i verapamila na abnorma'lnuiu aktivnos't zheludochkov v pozdneĭ stadii éksperimenta'lnogo infarkta miokarda.
• PMID: 2770089 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Tetrodotoxin
• Verapamil

Topics

• Animals
• Dogs
• Drug Synergism
• Drug Therapy, Combination
• Female
• Heart Block (drug therapy, etiology)
• Heart Ventricles (drug effects)
• Male
• Myocardial Infarction (complications)
• Tetrodotoxin (administration & dosage)
• Time Factors
• Verapamil (administration & dosage)