[Use of a cream based on 20% azelaic acid in the treatment of melasma].

Abstract

A 20% azelaic acid base cream (Skinoren-Schering) known in the treatment of acne has been used in melasma. The statistically processed results refer to 39 patients treated for 6 months with 2 applications/die. The reduction in melasma intensity was obtained in all patients bar two whose basal pigmentation situation was already compromised. Overall assessment on a graduated scale in cm evidences, after 6 months of treatment, a mean reduction in pigmentation of 51.3% understood as intensity and surface. The overall judgment of physician and patient on the preparation coincide with some 79% excellent and good on the part of the physician and 85% on the part of the patient. Noteworthy is the absolute absence of sensitisation or leukoderma or any of the other typical side-effects of the other depigmentants available thus far.

• Authors: C Rigoni, P Toffolo, R Serri, R Caputo
• Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia (G Ital Dermatol Venereol) 1989 Jan-Feb Vol. 124 Issue 1-2 Pg. I-VI ISSN: 0392-0488 [Print] Italy
• Vernacular Title: Impiego di una crema a base di acido azelaico 20% nel trattamento del melasma.
• PMID: 2767714 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dicarboxylic Acids
• Ointments
• azelaic acid

Topics

• Adult
• Aged
• Dicarboxylic Acids (administration & dosage, therapeutic use)
• Drug Evaluation
• Female
• Humans
• Male
• Melanosis (drug therapy)
• Middle Aged
• Ointments