Effect of T-activin on the course of experimental infection with Taenia crassiceps (Zeder, 1800) in mice.

Abstract

T-activin--an immunomodulating preparation of polypeptidic character prepared from calf thymus--was used for influencing the course of infection in a model system mouse-Taenia crassiceps. A single s.c. application of 100 micrograms of T-activin at various intervals before and after infection resulted in a marked decrease in the number of cysticerci in peritoneal cavities of experimental mice (by 47.1-93.6%) compared to the controls. After s.c. application of T-activin and i.p. injection of antigen (crude T. crassiceps larvae homogenate from mice) the decrease in the cystricercus number was still more pronounced than in the mouse groups receiving only T-activin or homogenate (by 76.9% in comparison with 65.5% and 17.0%, respectively). A combination of T-activin with crude T. crassiceps homogenate from rats did not produce the same effect in experimental mice. The protective effect of individual combinations of T-activin with the homogenate does not correlate with the antibody level in the serum of infected mice.

• Authors: J Hermánek, J Prokopic
• Journal: Folia parasitologica (Folia Parasitol (Praha)) Vol. 36 Issue 2 Pg. 117-26 ( 1989) ISSN: 0015-5683 [Print] Czech Republic
• PMID: 2767556 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antibodies, Helminth
• Peptides
• Thymus Extracts
• T-activin

Topics

• Adjuvants, Immunologic (therapeutic use)
• Animals
• Antibodies, Helminth (analysis)
• Disease Models, Animal
• Enzyme-Linked Immunosorbent Assay
• Mice
• Mice, Inbred ICR
• Peptides (therapeutic use)
• Peritoneal Cavity (parasitology)
• Taenia (immunology)
• Taeniasis (therapy)
• Thymus Extracts (therapeutic use)