HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Sustained-release verapamil as a first-step drug in the treatment of mild to moderate hypertension.

Abstract
The efficacy of sustained-release verapamil as a first-stage treatment for mild to moderate, uncomplicated essential hypertension was studied. Nineteen patients aged 36-70 years (mean +/- SD 55 +/- 10 years) entered the study. Treatment with 240 mg sustained-release verapamil, once daily for 8 weeks, caused systolic and diastolic blood pressures to decline significantly during the first 2 weeks and this lower level was maintained until week 8. Heart rate decreased gradually during the treatment period reaching significance at week 8. After 2 weeks maximum systolic and diastolic blood pressures during isometric exercise were significantly reduced compared with pre-treatment values; there was no difference in the percentage increase occurring pre- and post-treatment. These measures for heart rate did not change significantly. Except for a significant reduction in cardiac index after 8 weeks left ventricular function and left ventricular mass were unchanged. The 24-h urinary Na+ excretion increased significantly after 2 and 8 weeks' treatment. Plasma renin activity, serum lipid concentrations and routine blood chemistries were not affected. Side-effects were transient and did not require discontinuation of therapy. In conclusion, sustained-release verapamil is an efficacious and well tolerated first-stage drug in the treatment of essential hypertension.
AuthorsS M Karcier, B Orbay, A B Ozder, N Gürses, S Aytekin, S Satar, M Oztürk, C Demiroğlu
JournalThe Journal of international medical research (J Int Med Res) 1989 May-Jun Vol. 17 Issue 3 Pg. 268-76 ISSN: 0300-0605 [Print] England
PMID2767329 (Publication Type: Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Verapamil
Topics
  • Blood Pressure (drug effects)
  • Delayed-Action Preparations
  • Electrocardiography
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Hypertension (drug therapy, physiopathology)
  • Isometric Contraction
  • Male
  • Middle Aged
  • Physical Exertion
  • Verapamil (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: