Abstract |
The efficacy of sustained-release verapamil as a first-stage treatment for mild to moderate, uncomplicated essential hypertension was studied. Nineteen patients aged 36-70 years (mean +/- SD 55 +/- 10 years) entered the study. Treatment with 240 mg sustained-release verapamil, once daily for 8 weeks, caused systolic and diastolic blood pressures to decline significantly during the first 2 weeks and this lower level was maintained until week 8. Heart rate decreased gradually during the treatment period reaching significance at week 8. After 2 weeks maximum systolic and diastolic blood pressures during isometric exercise were significantly reduced compared with pre-treatment values; there was no difference in the percentage increase occurring pre- and post-treatment. These measures for heart rate did not change significantly. Except for a significant reduction in cardiac index after 8 weeks left ventricular function and left ventricular mass were unchanged. The 24-h urinary Na+ excretion increased significantly after 2 and 8 weeks' treatment. Plasma renin activity, serum lipid concentrations and routine blood chemistries were not affected. Side-effects were transient and did not require discontinuation of therapy. In conclusion, sustained-release verapamil is an efficacious and well tolerated first-stage drug in the treatment of essential hypertension.
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Authors | S M Karcier, B Orbay, A B Ozder, N Gürses, S Aytekin, S Satar, M Oztürk, C Demiroğlu |
Journal | The Journal of international medical research
(J Int Med Res)
1989 May-Jun
Vol. 17
Issue 3
Pg. 268-76
ISSN: 0300-0605 [Print] England |
PMID | 2767329
(Publication Type: Journal Article)
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Chemical References |
- Delayed-Action Preparations
- Verapamil
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Topics |
- Blood Pressure
(drug effects)
- Delayed-Action Preparations
- Electrocardiography
- Female
- Heart Rate
(drug effects)
- Humans
- Hypertension
(drug therapy, physiopathology)
- Isometric Contraction
- Male
- Middle Aged
- Physical Exertion
- Verapamil
(therapeutic use)
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