Abstract | UNLABELLED: The aim of this study was to evaluate the clinical efficacy of short and long-term treatment with famotidine 40 mg/daily at bed time in duodenal ulcer disease. 45 patients with endoscopically proven active duodenal ulcer undertaken the study. Endoscopic evaluations were performed at 6 weeks, 3 and 6 months from the start of the study. The following parameters were evaluated: pepsinogen group I and gastrin levels in serum, pH, acid and neutral glycoprotein, N-acetylneuraminic acid, pepsin in gastric juice collected during the upper gastrointestinal endoscopy. 6 weeks healing rate was 91.1%. After the third month of follow-up 14.2% of the patients presented an endoscopical proven episode of relapse. No relapses were observed at the end of the study (after 6 months of treatment). Acid glycoprotein, N- acetylneuraminic acid and pepsin concentrations significantly decreased after 6 weeks of treatment (p less than 0.0125, p less than 0.025, p less than 0.005 respectively), while serum levels of pepsinogen group I, gastrin and gastric pH increased (p less than 0.0005, p less than 0.005, p less than 0.025). After 6 months period of therapy, a significant increase of neutral glycoproteins (p less than 0.01) and a decrease of pepsin (p less than 0.005) and acid glycoproteins (p less than 0.01) was observed. On the contrary, gastric N- acetylneuraminic acid, pH, serum gastrin and pepsinogen group I presented the pre-trial values. IN CONCLUSION: 1) famotidine appears to be an effective and safe therapy for duodenal ulcer treatment; 2) it seems to act not only by inhibiting gastric acid secretion but also influencing some parameters related to the gastric mucosal barrier.
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Authors | A Vio, P Pasqualetti, L Gottardello, S A Grassi, F Vianello, L Dal Santo, P Tessaro, F Di Mario, R Naccarato |
Journal | Giornale di clinica medica
(G Clin Med)
Vol. 70
Issue 3
Pg. 195-201
(Mar 1989)
ISSN: 0017-0275 [Print] Italy |
Vernacular Title | La famotidina. Nel trattamento a breve e lungo termine dell'ulcera duodenale: studio clinico e fisiopatologico. |
PMID | 2759390
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Thiazoles
- Famotidine
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Topics |
- Adolescent
- Adult
- Aged
- Anti-Ulcer Agents
(administration & dosage, therapeutic use)
- Drug Administration Schedule
- Drug Evaluation
- Duodenal Ulcer
(drug therapy, physiopathology)
- Famotidine
- Female
- Humans
- Male
- Middle Aged
- Thiazoles
(administration & dosage, therapeutic use)
- Time Factors
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